The movie was made in the mid-1950s and naturally reflected the times, so there's a lot of references that echo the calls of Frederick Wertham. The comic artists themselves are portrayed as honest folks trying to earn a living, and the problem with gore and violence was pretty exclusively the fault of the publishers. But, ultimately, it's another Martin and Lewis film, one that gets increasingly frenetic and less coherent as it goes on.
Bob is probably the most famous within comicdom, as it starred Bob Newhart as a comic book artist and featured cameos of guys like Jack Kirby, Bob Kane, Sergio Aragones, Marc Silvestri and Jim Lee. Caroline in the City starred Lea Thompson as a comic strip artist. Less remembered for it's comic references are a few episodes of Mad About You wherein Eric Stoltz portrayed an ex-boyfriend who also happened to be launching a new comic.
In all these cases, the comic book artist profession is basically window dressing. The comedy comes from the quirks and neuroses of the various characters, their "wacky" neighbors, and often ludicrous plot contrivances set up for the sake of comedic reactions. (That's the very nature of situation comedies, after all.) And while there's mentions of deadlines and boneheaded publishers and that, they could just as often as not be applied to about any working profession.
All of the bits above, of course, were written by people who aren't in the comic business themselves. They're writers who are trying to emulate a comic environment, with varying degrees of success and/or accuracy.
Perhaps the most accurate interpretation I've seen -- certainly the most sincere -- is Derek Kirk Kim's Mythomania. The same Derek Kirk Kim who's won Xeric, Ignatz, Eisner and Harvey awards. It's available through YouTube and relays the trials and tribulations of Andy Go, aspiring comic book artist. Now there's a lot in the story that isn't directly related to comics, but Kim's been in the business for a while now so he knows what the life of a comic artist is really like. It includes a painful wall of rejection letters and small, uplifting moments when you receive a personally illustrated envelope.
It's interesting to see how the comic artist has been portrayed in other media over the years. I think it absolutely shows a reflection of how our culture at large views comic creators, and that we have increasingly more accurate and respectful works says a lot, I think.