Ken Kling created a strip called Joe Quince in the early 1920s. (I've seen start dates of 1923, '24 and '25.) The title character was on the hunt for a get-rich-quick scheme, and he frequently found out that there were no shortcuts. Despite that, however, he returned to gambling on horse races repeatedly, eventually befriending a stable hand known only as Asbestos. Kling evidently knew little about horse racing, though, and pulled horse names from actual races. And although Quince usually lost in the strip, the horses he bet on frequently won in the real world. Readers in the Baltimore area (the strip was never very widely distributed) started using it as a guide, believing Kling had some kind of inside information.
The Asbestos character initially became somewhat popular, and Kling changed the name of the strip to Joe & Asbestos. However, some papers continued calling it Joe Quince through 1926.
Kling seemed to broaden the strip's focus somewhat, although always kept horse racing as general theme. And sadly, he also kept the bad caricature that was Asbestos largely unchanged as well. Right up until his death in 1970. (That's based on the reading I've found. I haven't actually been able to find an instance of the strip after around 1945.) That this was largely left alone for so long seems to be primarily due to a very low syndication towards the end. In fact, it was only running in one paper for its last several years: The New York Daily News for most of those last years and then a brief run in The New York Mirror at the very end. Not to mention the niche focus of the strip meant a lot of people never bothered with it, even if it was in their paper.
It seems like a strange throwback. A strip so rooted in its time/place of origin that it never could outgrow that, but still managed to continue on despite that. If you look at other strips that started around the same time -- Gasoline Alley, Blondie, etc -- they made changes to reflect the society around them. Perhaps not as quickly as some readers would like (leading to complaints of retreading the same, tired jokes over and over again) but they changed nonetheless. That Joe & Asbestos didn't... honestly, I'm not sure what to make of that.